Animation TRP channel multimodulators in colds

Rights of use of the visual material: Procter & Gamble
Music: Kevin McLeod – Impact prelude – License: Creative Commons (CC BY 3.0)

Backgound:

Upper respiratory tract infections are diseases that affect the nose, nasopharynx and throat. They are common and can be caused by various viruses. The usual symptoms include cough, sore throat, runny nose and nasal congestion. Treatment for upper respiratory tract infections usually focuses on relieving symptoms.

Project description:

For Procter and Gamble, under the direction of the MSL Group, we created a 3D animation about the processes that are responsible for the discomfort of an upper respiratory tract infection. We focused on the inflammatory reactions in the epithelium of the nasal mucosa and the processes in the throat that cause coughing and sore throat. TRP (Transient Receptor Potential) receptors play an important role here.

In the second part of the 3D animation, the effect of various plant-based active ingredients on TRP receptors was shown. These are menthol, camphor and eucalyptus. Menthol and eucalyptus activate TRPM8 receptors located on the membrane of the nasal mucosa at the nerve endings. This has a reducing effect on the perception of nasal congestion, providing relief. At the epithelial cells in the throat, menthol interacts with TRPM8 receptors, and camphor and eucalyptus interact with TRPA1 receptors at the nerve endings, reducing the stimulus to cough.

Screenshots animation TRP channel multimodulators for colds: