Animation matrix metalloproteinase in wound management

Background

3D animation and illustrations of the role of matrix metalloproteinase (MMP) in wound healing. In normal wounds, matrix metalloproteinases break down damaged tissue to make room for new tissue. They also support cell migration and the formation of new blood vessels. MMPs therefore play an active role in the wound healing process.

Usage rights: Paul Hartmann AG
Music: Kevin McLeod – Impact prelude – License: Creative Commons (CC BY 3.0)

Project description

The animation shows an imbalance between MMPs and their inhibitors in a chronic wound. Here, the activity of matrix metalloproteinase is visibly increased. The proteases also break down healthy tissue. More and more tissue fragments are produced. These are bound to the receptors of the neutrophil granulocytes, which results in the release of further matrix metallo-proteases. This blocks the healing process.

The second part of the animation focuses on the removal of excess matrix metalloproteinases and their cofactors from the wound. MMPs and cofactors are stored in the HydroClean wound dressing, which restores the balance in the wound and enables normal wound healing.

Illustrations:

-> Link to video page “Animation matrix metalloproteinase in wound management”