MOA-Video Tianeptin for the treatment of depression

3D animation of the mode of action of Tianeptin in the treatment of depression. Focus on the processes at the AMPA receptor in the synapse gap of nerve cells.

Background

Glutamate is an important neurotransmitter in the central nervous system (CNS). It plays a central role in the transmission of nerve impulses and is involved in many important brain functions (e.g. learning, memory, movement control).

Glutamate also plays an important role in the development and treatment of depression. Changes in glutamate metabolism can be associated with mental illness.

Animation Tianeptin and depression

Rights of use of the visual material: Neuraxpharm
Music: Kevin McLeod – Impact prelude – License: Creative Commons (CC BY 3.0)

Project description

Design of a medical 3D animation about the mode of action of the antidepressant drug tianeptine in the treatment of mild, moderate and severe depression. The animation focused in particular on the modulating effect of tianeptine on the AMPA receptors in the hippocampus.

The first part of the animation shows stimulus transmission at a normal concentration of glutamate at the synaptic cleft. Glutamate is released from the pre-synapse into the cleft, where it docks onto AMPA receptors in the post-synapse. This allows ions to enter the postsynapse, where they change the charge concentration and ultimately transmit the stimulus.

In the next scene, an increased glutamate concentration in the synaptic cleft is discussed. Many ions enter the presynapse and many stimuli are transmitted. This has a detrimental effect on neuroneogenesis and cognition.

The active ingredient tianeptine acts on the glutamate system in the brain. It modulates the activity of NMDA and AMPA receptors, which are responsible for glutamatergic neurotransmission. This modulation appears to prevent or reverse stress-related changes in the brain, particularly in the hippocampus and prefrontal cortex.

Project details animation depression

Content: 3D Animation MOA-Tianeptin. Length 2:30 minutes. Language: German.

Utilization: Congresses, website, medical service

Specifications: Full-HD, 1920*1080 Pixel

Client: AWP Healthcare / Norexpharm

The rights of use of the illustrations shown are with the respective clients.

Screenshots animation

Brain with hippocampus
Brain with hippocampus
Effect active substance in the synapse cleft
Effect active substance in the synapse cleft
Increased ion concentration due to too much glutamate in the synaptic cleft
Increased ion concentration due to too much glutamate in the synaptic cleft
Glutamate activates AMPA receptors and opens ion channels
Glutamate activates AMPA receptors and opens ion channels
Tianeptin - synapse gap
Tianeptin – synapse gap
storyboard-antidepressant
Storyboard MOA animation antidepressant

-> Link to video page “MOA-Video Tianeptin for the treatment of depression”

More projects: