3D Animation Crohn’s disease

Background:

Crohn’s disease is a form of inflammatory bowel disease (IBD) that causes inflammation of the digestive tract. It can affect any part of the digestive tract from the mouth to the anus, but most commonly affects the lower part of the small intestine (ileum) and the beginning of the large intestine (colon).

Symptoms of Crohn’s disease include abdominal pain, diarrhea, weight loss, fatigue, and malnutrition. The exact cause of Crohn’s disease is not known, but it is thought to be a combination of genetic and environmental factors. The view that Crohn’s disease is a classic autoimmune disease is now considered outdated.

Rights of use of the visual material: Client (nda)
Music: Kevin McLeod – As I figure – License: Creative Commons (CC BY 3.0)

Description:

The focus of the 3D animation was the presentation of the processes in the immune system during a disease with Crohn’s disease. In particular, the function of various interleukins was addressed, which act as endogenous messengers of the cells of the immune system and play an important role in inflammatory processes.

The animation starts with a transparent person with intestinal problems. An inflamed area can be seen in the intestine.

A detailed view shows a defect in the upper cell layers of the intestinal wall. Invading bacteria activate dendritic cells, to which T helper cells attach themselves. The dendritic cell releases interleukin 12. The T helper cells differentiate into TH-1, proliferate and release cytokines.

In the following sequence, a macrophage releases interleukin 12, which migrates to TH-17 cells, which then release interleukin 22 and interleukin 17.

The cells of the intestinal wall lose their protective function and the inflammatory process accelerates. The animation concludes with a highly inflamed intestine.

Screenshots Crohn’s disease:

-> Link to video page “3D Animation Crohn’s disease”